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Additional monthly 100 mcg injections might be necessary based on symptom improvement and the cause of deficiency

This requires formal FDA approval, manufacturer consent, and Institutional Review Board (IRB) oversight

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Surprisingly, M2 macrophages inhibit CD8 + T cell enrichment and the proportion of interferon- + CD8 + T cells in the TME, resulting in immune evasion and anti-PD-1 resistance in HCC