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49 A deficit in the tricarboxylic acid cycle and ETC function under conditions of excessive superoxide production in the brain would be expected to result in a reduced ability to maintain adequate levels of ATP required for normal neuronal and synaptic functioning
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For cell colony formation assay, cells were seeded in 6-well plated at a density of 12 10 3 cells per well
Moreover, other molecules that are overexpressed in DS patients and are also related with cardiac hypertrophy could unveil similar questions: Are the elevated expression levels of DYRK1A, RCAN3 and DSCAM-AS1 involved in the cardiac hypertrophic response prevention observed in DS individuals
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