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It is a naturally occurring nonapeptide a chain of nine amino acids first identified in rabbit brain tissue in the 1970s

Given that there is no placebo-controlled human data, no established dose, and a mechanism whose foundational papers were retracted, an absence of noticeable effect is fully consistent with the current evidence it does not necessarily indicate a defective product, the wrong route, or an insufficient duration

Arginine, although not required in the diets of adults, is required for growth (children and adolescents), because the amounts that can be synthesized are not sufficient to maintain normal growth rates

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doi:10.1186/s12916-025-04276-8 Lu XT, Wang YN, Mo QW, et al