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10.1016/j.neuron.2022.07.003 Neuron 60 LiuJ.TozziF.WaterworthD.PillaiS.MugliaP.MiddletonL.et al (2010)

Changes in ADME result from interactions between drugs that affect different biological targets in the body, such as enzymes, receptors, or ion channels ( Nutrient synergy is commonly discussed in nutrition with regards to the way nature provides a multitude of nutrients in whole food sources (Figure 1)

Some protocols combine approaches, using local injection near primary wounds with periodic systemic dosing for comprehensive support

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