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With regard to the substantial clinical improvement criterion, the applicant asserted that NexoBrid TM represents a substantial clinical improvement over existing technologies because it is associated with reduced time to complete eschar removal, prevented burn depth conversion, reduced overall surgical burden, reduced blood loss, and reduced incidence of autografting

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In addition, this enzyme was also found in the nucleolus of various cell types, such as human HeLa cells, mouse L929 cells (fibroblast cell line), but also in mouse testes, specifically in spermatogonia, spermatocytes and spermatids