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Hydrogen-peroxide-induced heme degradation in red blood cells: the protective roles of catalase and glutathione peroxidase

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Although normal electron transport in mitochondria involves four-electron reduction of O 2 to water, partial reduction reactions occur under physiological conditions, causing release of superoxide anion and hydrogen peroxide (H 2 O 2 )

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In some individuals, more severe psychiatric manifestationssuch as depressive disorders, manic episodes, or psychotic symptomshave also been described ( 6.2 Neurobiological and cognitive effects Neurobiological research suggests that AAS exposure may affect central nervous system functioning by inducing both structural and functional alterations