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Effect sizes and mechanisms cannot be assumed to translate directly to human physiology
Impaired adipose tissue lipid storage, but not altered lipolysis, contributes to elevated levels of NEFA in type 2 diabetes
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Tirzepatide's dual mechanism of action, activating both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the GLP-1 receptor, produces superior metabolic effects compared to GLP-1-only approaches demonstrated in head-to-head clinical data and confirmed commercially by its rapid market penetration
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