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In addition, NRF2 can also regulate the transcriptional expression of metabolites involved in intermediate metabolism, some of which play essential roles in the regeneration of NADPH, a key electron donor needed to reduce oxidative substrates [108]

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Several studies have also observed that co- and multi-morbidities, like cardiovascular disease, diabetes, and osteoporosis, which are normally witnessed later on in life as a result of natural aging, were increasingly prominent among the HIV-infected population (Guaraldi et al., 2011)

Indeed, coenzyme Q10 is listed as one of the most commonly used treatments in migraine prevention [20,79]

Each hepatocyte appeared polyhedral with acidophilic granular cytoplasm