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Histological analysis revealed that Dihexa treatment increased neuronal cell counts and enhanced expression of synaptophysin (SYP), a presynaptic protein marker indicating synaptic density, in the hippocampus of APP/PS1 mice

CMS Transmittal 13673 (CR 14392) updated the MPFSDB effective April 6, 2026

The compound has been evaluated in multiple preclinical models for its role in modulating adipose tissue and lipid metabolism without mimicking the full spectrum of hGH activity (Heffernan et al

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These protective effects are mediated, in part, through modulation of key inflammatory pathways central to asthma pathophysiology, summarized in Table 2