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In addition, higher levels of free iron combined with other risk factors such as genotoxic metabolites of estradiol, alcohol consumption, and ionizing radiation can increase the likelihood of breast carcinogenesis [26]

Preclinical anabolic effect in catabolic states Tomas et al

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While cells have higher permeability with Asn than Asp, the activity of asparaginase in bladder cancer cells was insufficient, which could not convert Asn into Asp