The choice of treatment should be individualised, considering the underlying cause, symptom severity, patient preference, and practical factors such as access to healthcare facilities for regular injections
The well-known geriatrician-haematologist Larry Solomon, working at Yale University in the USA, wrote 20 years ago: if I had treated only those people who actually had too low serum B12 and elevated MMA values, then I would not have treated approximately two-thirds of the people with a favourable response to B12 supplementation (note: partly via injections, partly via oral supplementation)
These include serious infection, uremia or renal failure, drugs with bone marrow suppression properties (e.g., chloramphenicol), or concurrent undiagnosed folic acid or iron deficiency anemia
For someone starting at 220 pounds, that translates to roughly 46 pounds of total weight reduction over a standard treatment course
Would highly recommend Optimized Body and mind