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The combination is used in clinical practice under physician supervision based on mechanistic reasoning, preclinical evidence, and clinical experience

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Preclinical research has examined its role in promoting angiogenesis, reducing oxidative stress in intestinal tissue, and interacting with the nitric oxide system to modulate gut blood flow

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The use of dose-adjusted DOACs in the subgroup of patients with AFib in the pivotal RCTs did not result in a significant interaction between dose adjustment and therapeutic effects of DOACs with respect to the primary clinical outcomes