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The additional daily injections, timing requirements (fasted administration for AOD 9604), and cost may not justify whatever incremental benefit exists

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Beginners should start at 250 mcg daily to assess individual tolerance and response before potentially increasing the dose

This can lead to reduced insulin-mediated glucose uptake in muscle cells in vitro and in animal models, resulting in reduced insulin sensitivity and higher insulin resistance in the offspring [45, 46]

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