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Athletes and fitness enthusiasts appreciate this benefit, as it allows for fat loss while maintaining or even improving strength and performance

When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure

This targeted mechanism minimizes the risk of off-target effects and supports the compounds favorable safety profile

Through its modulation of the NNMT-SAM-NAD+ axis, it enhances energy expenditure and supports more efficient utilization of fat stores for energy, making it a strong candidate in studies exploring metabolic optimization and obesity control

Segata, N