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Metastases have been reported, most commonly in the lungs ( Our case presents a cervical intra- and extraspinal MMNST without PRKAR1A mutation or copy number changes, a finding rarely documented in the literature

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Nanoparticles are used to deliver and control drug release and adjust the intracellular chemical reaction to affect the ROS levels, thereby improving the pharmacokinetic properties of the drug [58, 195, 196]

Severe encephalopathy associated to pyruvate dehydrogenase mutations and unbalanced coenzyme Q10 content