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48 Also, treatment of mice with polydatin, which elevates Gli1, has been shown to restore BBB function following ischemic insult

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Erythropoiesis is the single largest consumer of iron, quintessential for hemoglobin (Hb) synthesis in the body

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L-carnitine metabolism to GBB, crotonobetaine, and TMA (and ultimately TMAO) could affect L-carnitine availability for bioenergetics, particularly if biosynthesis is also impaired and/or there is an increased reliance in FAO for energy production (i.e., an increased demand for L-carnitine)