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Your blood vessels clamp down like tightening fists around garden hoses Oxygen-rich blood slows to a trickle through constricted passages Brain regions starve for adequate perfusion within seconds This vasoconstriction explains why you feel lightheaded almost immediately after nicotine exposure

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doi:10.1038/s41598-020-67047-w 402

1-3/5-GABA A receptors (and therefore benzodiazepine sites) are highly expressed across the hippocampus [49, 50], and although there are slight differences in the levels of 1-3/5 receptor subunits across hippocampal subfields [74], hippocampal subfields are highly interconnected [75]