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Overall, HTP expose users and bystanders to substantially fewer harmful and potentially harmful compounds than smoking cigarettes. In 2019, the FDA allowed the tobacco company Philip Morris International to start selling IQOS in the US

There could be huge health benefits from policies that incentivize consumers in LMICs to substitute combustible cigarettes for alternative forms of nicotine and this is an area that (to the best of my knowledge) is completely un-funded by philanthropy