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Occasionally, liver biopsy is needed to help in the diagnosis of a sudden onset of autoimmune hepatitis, drug-induced liver injury, diffuse intrahepatic malignancy not identified on imaging, Wilson disease, alcoholic liver disease when clinical history is uncertain, and unusual infections such as herpes or Q fever

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Handle according to established laboratory procedures

Cloudiness after reconstitution usually indicates contamination or improper preparation

It can trigger fraud investigations if the pattern suggests systematic upcoding or indication mismatches