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The SARS-CoV-2 infection initiates complex human host-pathogen interactions and alters mitochondrial function with significant disruption of glycolysis/TCA cycle (Warburg effect), affecting several metabolic pathways of amino acid (AA), fatty acid (FA), nucleotide, and antioxidant synthesis 139,140

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The positive correlation between exposure to BPA and the level of NOX1 in the serum of women with miscarriage shown by the present study suggests the existence of a relationship between high BPA concentration and increased activity of the NADPH oxidase complex, which may result in miscarriage through the activation of ROS/NETs pathway