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C-X3-C Motif Chemokine Ligand 1 (CX3CL1)- C-X3-C Motif Chemokine Ligand 1 receptor (CX3CR1) and OX-2 membrane glycoprotein (CD200)-OX-2 membrane glycoprotein receptor (CD200R) form ligand-receptor pairs, and these molecules are the most important chemokines and clusters of differentiation in maintaining CNS homeostasis

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In addition, citrulline, a major precursor for endogenous arginine, supplementation has been shown to restore systemic arginine levels, improve airway NO production, and asthma control in individuals with obesity-related asthma [124]

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