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The first suggests that we need to recognise that quit attempts occur frequently, and that further increasing the frequency of these attempts and the rate of success on these attempts may be required to reduce smoking prevalence in a population

We found that CHANGE-seq-BE sensitively identifies not only off-target activity but also unintended on-target activity of contaminating synthetic gRNAs, highlighting one of the advantages of using unbiased sensitive methods for genome-wide assessment of genome-editing activity