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This substance is what makes it so hard to quit smoking or vaping Nicotine (noun, NIH-coh-teen) Nicotine is an addictive substance found mostly in tobacco plants

[9] Viennet, C., Bride, J., Armbruster, V., Aubin, F., Gabiot, A.C., Gharbi, T

[86] Nicotine is a parasympathomimetic stimulant [89] that binds to and activates nicotinic acetylcholine receptors in the brain, [90] which subsequently causes the release of dopamine and other neurotransmitters, such as norepinephrine, acetylcholine, serotonin, gamma-aminobutyric acid, glutamate, endorphins, [91] and several neuropeptides, including proopiomelanocortin-derived -MSH and adrenocorticotropic hormone

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