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Further evidence for this notion comes from observations that Prx5 downregulation correlates with downregulation of molecular chaperones, and upregulation of proteins associated with neuroinflammation (Knoops et al., 2016)

O'Leary ME, Chahine M (2002): Cocaine binds to a common site on open and inactivated human heart (Nav1.5) sodium channels

Cleavage of these proteins which are essential for docking to and fusion of acetylcholine vesicles with the inner side of the nerve terminal membrane results in the inhibition of neurotransmitter release at neuromuscular junctions

Glutathione is a powerful antioxidant that safeguards cells against oxidative stress

Andreeff M , Carter B, Konopleva M, Zhao S, Tsao T, Weidner D, Estey E, Lopez-Berestein G, Estrov Z, Altieri D, Kornblau SM, Reed JC