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The complementary mode of actions of amylin-analogues and GLP-1RAs (CagriSema) appear to be a promising combination therapy with weight loss of up to -15.6% after 32 weeks of treatment, comparable to that of tirzepatide [19]

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TML is then hydroxylated by 6-N-trimethyllysine dioxygenase (TMLD), which is located in the mitochondrial matrix, to form 3-hydroxy-6-N-trimethyllysine (HTML)