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Mechanistically, GSTM2 interacted with ASK1 and suppressed its phosphorylation and the activation of subsequent downstream p38-JNK signalling

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One such drug, siltuximab, a chimeric anti-IL-6 antagonistic antibody, received FDA approval for treating multicentric Castleman disease and is currently being investigated for treating cancers

for the cis isomer (synperiplanar conformation), and for the trans isomer (antiperiplanar conformation)