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Furthermore, Glu296 interacts with the side chain of Glu211, an interaction that has been shown to cause an increase in the apparent pKa

Elevated glutamate levels can play a role in promoting cytotoxic edema by raising intracellular sodium levels and facilitating the movement of water into the cells, subsequently increasing the volume of intracellular fluid (Yi and Hazell, 2006)

FDA will not take enforcement action with regard to the storage or emergency use of these lots of Relenza, provided that the products have been stored under labeled storage conditions

What to expect: Immune modulation is a gradual process