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Misra, M

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The first study ex vivo in Ussing chambers (1999) evaluating the epithelial barrier function in colonic tissue from UC patients with mild or moderate macroscopic disease activity showed a 50% decrease of the total electrical wall resistance (assessed by transmural impedance analysis) when compared to healthy subjects

Pro-inflammatory cytokines like TNF-alpha, IL-1beta, and IL-6 damage surviving nerve fibers, interfere with Schwann cell repair functions, and create a hostile environment for axonal regrowth

The selective action remains advantageous for lean individuals because it targets fat specifically without promoting water retention or tissue growth that might obscure definition