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Data from early studies suggest that chronic stress causes prolonged periods of stimulated glutamate release following acute stress exposure, at least in the hippocampus That review is a great review of how stress hormones (like cortisol) and glutamate are toxic to the brain when exposed long term

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doi: 10.1016/j.pmn.2024.11.006, PMID: [DOI] [PubMed] [Google Scholar] 24

Summary Melatonin is promising for the correction of sleep and circadian abnormalities in psychiatric disorders

Previously, these bite cells were considered a consequence of splenic removal of Heinz bodies