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Eight weeks of aerobic exercise significantly activated the System Xc /GPx4 signaling pathway in the prefrontal cortex of APPswe/PS1dE9 transgenic AD mice, up-regulated FTL and BACE1 expression, significantly downregulated 4-HNE levels, inhibited oxidative stress, lipid peroxidation, and ferroptosis, reduced A positivity, alleviated neuronal morphological abnormalities, and improved learning and memory functions in AD mice (Li et al., 2024a)

They target aging through entirely different mechanisms, which means the comparison matters more for sequencing and stacking than for choosing one over the other

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At present, there is limited evidence that increasing glutathione beyond normal physiological levels provides additional health benefits in otherwise healthy individuals.