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In addition, hepatic dysfunction or genetic mutations affecting UDP-glucuronosyltransferase ( UGT1A1 ) hobby can impair the conjugation of bilirubin, increasing the threat of precipitation [34]

doi:10.1016/j.freeradbiomed.2011.04.013

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The primary endpoint for the EMA was the percentage of patients achieving a SALT 10 at week 24, and the key secondary endpoint was improvement in the Patient's Global Impression of Change (PGI-C), defined as a rating of moderately improved or much improved at week 24 (PGI-C: a 7-point patient scale ranging from very much improved to very much worse).8 Baseline demographic and disease characteristics were balanced among treatment groups: 15% of patients were adolescents, 62% were women, 68% were White, and 46% had AT or AU