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To test this, GPx1 expression was partially knocked down in macrophages from healthy volunteers and this resulted in increased H 2 O 2 -induced cell death and lipid peroxidation without H 2 O 2 treatment, implying that GPx1 is important in the homeostatic maintenance of cellular lipid redox

Anecdotally, users in the recovery and biohacking space report meaningful subjective improvement in joint comfort and training tolerance, but that's self-report, not controlled data

This does not mean higher doses are beneficial, only that accidental overdose within reasonable ranges carries minimal acute risk

Proc Natl Acad Sci USA 95 : 30713076