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The active GSH rapidly oxidizes into the inactive GSSG
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This is achieved by initiating Ca 2+ channels on the tumor cell membrane, leading to the inward flow of extracellular Ca 2+
doi: 10.3389/fimmu.2025.1709561 Received 20 September 2025 Revised 16 October 2025 Accepted 11 November 2025 Published 26 November 2025 Volume 16 - 2025 Edited by Juan Pablo de Rivero Vaccari, University of Miami, United States Reviewed by Emir Malovic, University of Illinois Chicago, United States Anna Maria Sardanelli, University of Bari Aldo Moro, Italy Updates Copyright 2025 Tu, Han, Zhang, Jia, Sun, Liu, Li, Tang and Wang
3.5 High mobility group box 1 and inflammatory signaling HMGB1, a nuclear protein, functions as a transcription factor and a DAMP that amplifies inflammatory responses ( + T cell activation and function
