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This effect is related to the synthesis of nerve myelin lipids and the maintenance of the integrity of sheathed nerve fibers

This is generally mild and self-limiting, but if headaches persist beyond the first week or are significant, stopping use and consulting a doctor is the sensible approach rather than continuing through discomfort

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The sealed system maintains sterility through the crimped rubber stopper, and benzyl alcohol remains stable across this temperature range for the full shelf life printed on the label