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Collectively, our findings emphasize brain regions (e.g., vmPFC, insula, thalamus) and circuits (e.g., insula-thalamus) linked with chronic smoking, suggest neuroimaging paradigms warranting additional consideration among smokers (e.g., pain processing), and point to regions in need of further elucidation in addiction (e.g., cerebellum)

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Moreover, acetaldehyde increases the permeability of intestinal tract by reducing the expression of tight-junction and adherent- junction proteins of intestinal mucosa