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[DOI] [PubMed] [Google Scholar] Rebbeor JF, Connolly GC, Dumont ME, Ballatori N

As a result, there was a rapid appearance of pale flat areas and a rapid disappearance of mucosal folds (Table 1 and Figures 2-4)

The activities of these enzymes reduce the availability of amino acids (for example, tryptophan, arginine, histidine, and threonine) to surrounding T cells, inhibiting mTOR signaling via the lipid phosphatase PTEN and blocking the proliferation of Teff cells, thus promoting Treg cell induction (183)

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Further exploration of the mechanism, both the inhibitors 5a and 5b were found to be reversible and competitive