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However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12particularly from supplements or injectionsmay be associated with certain health concerns, though these are correlations rather than proven causal relationships

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They have been shown to prevent the decline in leukocytes and thrombocytes in patients undergoing radiation treatment, which resulted in reduced mortality (Magnusson 2011)

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While glutathione is naturally present in the body and plays important roles in fetal development, intentional supplementation with injectable forms has not been adequately studied to establish safety during pregnancy or breastfeeding