The analogues were synthesised via Fmoc-solid-phase peptide synthesis, and they were characterised using reverse-phase high-performance liquid chromatography (RP-HPLC), electrospray ionisation mass spectrometry (ESI-MS), Fourier-transform infrared spectroscopy (FTIR), and nuclear magnetic resonance (NMR) spectroscopy
Ding X, Cao Y, Huang L, Zhao J, Xu C, Li X, Wang S
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The FDA has determined that NAC is excluded from the statutory definition of a dietary supplement under the Federal Food, Drug, and Cosmetic Act, because NAC was authorized as an active pharmaceutical ingredient (for acetaminophen overdose) before it was widely marketed as a supplement
Doi: Irving C, Basu A, Richmond S, Burn J, Wren C (2008) Twenty-Year Trends in Prevalence and Survival of Down Syndrome