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Is well know that ROS presence does not have to be considered only as a harmful effect: experimental research has extensively demonstrated that in physiological conditions ROS signaling as a second messenger in cells is crucial for a variety of biological actions, such as gene expression, signal transduction, and receptors activation [12-13], and also wound healing, tissue regeneration and protection from pathogens [14-15]

Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver

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