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Berlin: Springer-Verlag Berlin Heidelberg

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Patients and Methods: Patients (N = 188) were grouped into cohorts A, B, or C based on the method for initial dose calculation and estimation of AUC: Cohort A: Initial doses were based on the conventional dosing algorithm (as outlined in the manufacturers' package insert) and non-compartmental analysis (NCA) estimation using the trapezoidal rule for estimation of AUC following TDM

The anxiolytic mechanism of Selank involves modulation of GABAergic neurotransmission through allosteric effects on GABA-A receptor sensitivity, distinct from the direct binding site used by benzodiazepines