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Similarly, dysregulation of System Xc- limits cysteine availability, impairing glutathione synthesis and escalating oxidative stress

296 Unlike PGC-1, PGC-1 appears to be a double-edged sword in HCC

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Similarly, disrupting the aberrant vasculature of tumors with anti-angiogenic agents, in tandem with hypoxia-activated prodrugs, may lead to improved drug delivery and therapeutic outcomes (311, 315)