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Mechanistically, acetyl-CoA, a derivative of BCKAs, inhibits the interaction between PR domain-containing protein 16 (PRDM16) and peroxisome proliferator-activated receptor- (PPAR-) by acetylating the k915 site of PRDM16 to maintain WAT characteristics

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Out of 41 RCTs, 39 studies have shown a significant lowering effect of L-carnitine supplementation on FBG (mg/dl) (80), 19 studies on serum insulin (pmol/l) (76, 80), 20 studies on serum HbA1c (%) (74, 77, 79, 80), and 17 studies on HOMA-IR (73, 75)