Also known as: Insulin-Like Growth Factor 1, Somatomedin C, IGF-I
However, there are evidence that suggest senescence have a tumor promoting effect, owing to the proangiogenic influence of some components of senescence-associated secretory phenotype (SASP) such as vascular endothelial growth factor (VEGF) or the impact of senescent fibroblasts on adjacent tumor cells 35,36
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ALDOA is overexpressed in most cancers, while ALDOB is often downregulated
Proteins were further purified by size exclusion chromatography using HiPrep 16/600 Superdex 75 columns (GE Healthcare) in buffer 50 mM Tris pH 7.5, 150 mM NaCl, and 5 mM DTT