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Sighs are reported to result from activation of a neuronal circuit in the preBtzinger complex/parafacial group 133 while apnea results from direct inhibition of the preBtzinger complex or inhibition of drive to phase-switching neurons in the preBtzinger complex 134

In fact the ELF concentration of GSH is 140 times that of blood serum concentrations with a redox ratio of greater than 9:1

Both approaches show effectiveness, with selection depending on injury characteristics