It is very important to note that the noxious effects of ROS and pro-inflammatory factors presents in the follicular fluid of ENDO patients (such as IL-6, TNF-) would be even more accentuated in human ovary where oocytes are exposed to follicular fluid at higher concentrations and for longer periods of time than in the current study
although less potent than Erastin in vitro , its feasibility for systemic dosing and observed ferroptosis linked sensitization in difficult models underscore its translational relevance (84)
10.1021/acsomega.0c05950 [DOI] [PMC free article] [PubMed] [Google Scholar] Siow, H
(More information) The current recommended dietary allowance (RDA) is 15 mg/day of -tocopherol
The cell uses different antioxidant defenses, including superoxide dismutase, catalase, glutathione detoxification pathways, and thioredoxin detoxification pathways (Kudin et al., 2012)