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The apolipoprotein E4 genotype contributes to the abnormal accumulation of lipid droplets (LD) in microglia and the formation of neurotoxic LD-accumulating microglia, which are capable of directly inducing neuronal Tau phosphorylation and apoptosis, and the degree of LD accumulation is positively correlated with the severity of cognitive decline and pathology [148]

The findings suggest that the release of CGRP , regulated by 17-estradiol, can partially explain the gender difference in sensitivity to visceral pain

Variants with extended half-life have been explored for their capacity to sustain elevated growth hormone signaling over longer periods while preserving pulsatility

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10.1016/j.pscychresns.2011.06.014 Psychiatry Res