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HD is induced by the expansion of CAG repeats in the Huntingtin (Htt) gene, resulting in the formation of mutant Huntingtin (mHtt) (Figure 4E

Importantly, preclinical studies showed that weight reduction occurred particularly in abdominal adipose tissue, the visceral fat depot most strongly associated with metabolic health risks

For people not eating any animal products, yeast extract and other fortified/supplemented foods such as breakfast cereals, soya milks, soya/veggie burgers, and vegetable margarines are all good sources

This either suggests a genuinely pleiotropic mechanism or that some of the reported effects are artifacts of study design or publication concentration in a single research group

To test the involvement of NRF2, we bred the Gclc f/f mouse strain with the Nrf2 f/f mouse strain 57,58 and induced a liver-specific double deletion with the AAV-TBG-Cre virus (hereafter referred to as L-DKO) (Fig