Efficacy of Transdermal Estradiol and Micronized Progesterone in the Prevention of Depressive Symptoms in the Menopause Transition: A Randomized Clinical Trial
However, it still lacks long-term human clinical data on its efficacy and safety profile
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MetS is a complex group of abnormal metabolic symptoms that are closely associated with cardiovascular disease (CVD), including a state comprising abnormal lipid metabolism, hypertriglyceridemia, lowered high-density lipoprotein (HDL) cholesterol, increased arterial blood pressure, and impaired glucose tolerance [4, 5], which progressively causes hypertension, central obesity, insulin resistance (IR), dyslipidemia, and dysregulation of glucose homeostasis, increasing the risk of individuals developing type 2 diabetes mellitus (T2DM) and CVD [6, 7]