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Moreover, the inhibitory effect on cell proliferation and ODC activity induced by cigarette smoke may be reversed by exogenous spermidine, indicating that the delayed wound healing in the stomach induced by cigarette smoke was at least in part due to a reduction in polyamine synthesis (30,32)

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14 Nortriptyline dosing recommendations for smoking cessation: 15, 17 Step 1 set a quit date Step 2 initiate nortriptyline 10 28 days before this quit date, initially at a dose of 25 mg daily Step 3 increase the dose gradually over ten days to five weeks to 75 100 mg Step 4 continue use for three months in total (can be continued for up to six months, if required) Doses should be slowly tapered when stopping nortriptyline to avoid withdrawal symptoms

However, acceptance of this assumption for more than three decades may have led to inadequate interventions and reduced concordance with the treatment of nicotine dependence in people with schizophrenia (Manzella Reference Manzella, Maloney and Taylor2015)