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Based on data from the literature and our preliminary study after a 4-day subacute exposure (data not shown), two exposure protocols were applied in this study for both e-cig and 3R4F emissions: a 3-month subchronic and a 6-month chronic exposure, 60 min/day and 5 days/week

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The CYP2C9*3 gene variant, codes for a version of the CYP2C9 enzyme that metabolizes molecules slower than its standard form (3)

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